Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) could also be extra advantageous than multiparametric magnetic resonance imaging (mpMRI) for detecting biochemical recurrence (BCR) of prostate most cancers (PCa), based on a brand new meta-analysis.
For the meta-analysis, lately printed in Present Urology, researchers reviewed information from 5 comparative research (together with a complete of 225 sufferers) analyzing the usage of PSMA PET/CT and mpMRI for diagnosing PCa BCR in the identical affected person cohorts.
The researchers discovered that PSMA PET/CT had an general positivity charge of 68 p.c for detecting BCR of PCa in distinction to 56 p.c for mpMRI. PSMA PET/CT additionally had a 44 p.c positivity charge for lymph node metastasis compared to 25 p.c for mpMRI, based on the meta-analysis authors.
In a brand new meta-analysis, researchers discovered that PSMA PET/CT offered considerably higher positivity charges than mpMRI for the detection of biochemical recurrence of PCa and lymph node metastasis, and comparable positivity charges for native PCa recurrence.
“Proof from this research means that PSMA PET/CT has a better positivity detection charge for BCR and lymph node metastases than that of mpMRI,” wrote the meta-analysis co-authors Xinru Zhang, M.D., and Zhe Ma, M.D., who’re affiliated with the Division of Ultrasound on the First Affiliated Hospital of Shandong First Medical College in Jinan, China.
The meta-analysis authors stated PET/CT has distinctive attributes that might facilitate earlier detection of PCa recurrence.
“Positron emission tomography/computed tomography is a novel diagnostic device that has demonstrated its distinctive diagnostic properties in most cancers, significantly for PCa. The flexibility to develop radiolabeled tracers for useful imaging based mostly on PCa cell traits might doubtlessly present further data by exploiting key options of those cells, resembling metabolic exercise, elevated proliferation, and receptor expression,” added Zhang and Ma.
Three Key Takeaways
1. Greater detection charges with PSMA PET/CT. PSMA PET/CT demonstrates a better positivity detection charge for biochemical recurrence (BCR) of prostate most cancers (PCa) and lymph node metastases in comparison with multiparametric MRI (mpMRI). The meta-analysis reported a 68 p.c positivity charge for BCR with PSMA PET/CT, in comparison with 56 p.c with mpMRI, and a 44 p.c positivity charge for lymph node metastasis in comparison with 25 p.c with mpMRI.
2. Distinctive Diagnostic Attributes of PET/CT. The researchers famous the potential of PET radiolabeled tracers for useful imaging based mostly on prostate most cancers cell traits. This enables for extra element into options like metabolic exercise and receptor expression, doubtlessly facilitating earlier detection of recurrence.
3. Limitations and Concerns. The meta-analysis highlighted limitations, together with the low variety of reviewed research and lack of analysis of benign lesions. The authors additionally cautioned in opposition to broad extrapolation of positivity charges because of research variations, resembling biomarker thresholds and follow-up period, which may affect outcomes. There was no vital distinction noticed between PET/CT and mpMRI for detecting native PCa recurrence.
Nevertheless, the researchers famous no vital distinction between PET/CT and mpMRI within the detection of native PCa recurrence (37 p.c vs. 38 p.c).
Zhang and Ma additionally cautioned in opposition to broad extrapolation of the meta-analysis findings on positivity charges for PCa recurrence, noting a scarcity of acceptable ranges of heterogeneity for each PET/CT and mpMRI after a sensitivity evaluation. Additionally they advised that research variations with respect to biomarker thresholds and follow-up period can affect outcomes.
(Editor’s notice: For associated content material, see “How Efficient is mpMRI at Detecting PCa in Biopsy-Naïve Sufferers?,” “Detecting PCa Recurrence in African People: Can 18F-Flotufolastat Have an Impression?” and “SNMMI: PSMA-18F DCFPyL Modifications Therapy for PCa Recurrence in Vital Variety of Sufferers with Low PSAs.”)
In regard to limitations of the meta-analysis, the authors conceded the low variety of reviewed research. Additionally they acknowledged that the meta-analysis didn’t embody analysis of benign lesions. The researchers additionally famous there was no evaluation of accuracy or specificity charges for PET/CT or mpMRI.
